A nucleophile (or nucleophilic
reagent) is a
reagent that forms a
bond to its reaction partner (the
electrophile)
by donating both bonding electrons. A '
nucleophilic substitution
reaction' is a
heterolytic reaction in which the
reagent supplying the
entering group acts as a nucleophile. For
example:
The term '
nucleophilic' is also used to designate the
apparent polar character of certain
radicals,
as inferred from their higher relative reactivity with reaction sites
of lower
electron density. Nucleophilic reagents are
Lewis bases.
Source:
PAC, 1994, 66, 1077
(Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994))
on page 1146
InChI=1/C2H5Cl/c1-2-3/h2H2,1H3
InChI=1/ClH/h1H/p-1/fCl/h1h/q-1
HRYZWHHZPQKTII-UHFFFAOYAJ
VEXZGXHMUGYJMC-QOKNLKRHCF
Cite as:
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by
A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997).
XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic,
J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
https://doi.org/10.1351/goldbook.
