Interaction between the
substrate binding sites of an
allosteric enzyme. Binding of a substrate molecule to one
binding site changes the affinity of the binding sites on the other subunits (cf.
allosteric enzymes) to the substrate by induction of a
conformation change at the other binding sites. Cooperative
enzymes typically display a sigmoid (S-shaped) plot of the reaction rate against substrate
concentration.
Source:
PAC, 1992, 64, 143
(Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992))
on page 151
Cite as:
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by
A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997).
XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic,
J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
https://doi.org/10.1351/goldbook.
