Ratio of the systemic
exposure from extravascular (
ev) exposure to
that following intravenous (
iv) exposure as described by the equation:
where
is the bioavailabilty,
and
are areas under the (plasma)
concentration-time curve following extravascular and intravenous
administration, respectively, and
and
are the administered
extravascular and intravenous doses.
Source:
PAC, 2004, 76, 1033
(Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003))
on page 1041
Cite as:
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by
A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997).
XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic,
J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
https://doi.org/10.1351/goldbook.
