Ratio of the systemic
exposure from extravascular (
ev) exposure to
that following intravenous (
iv) exposure as described by the equation:
where
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is the bioavailabilty,
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and
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are areas under the (plasma)
concentration-time curve following extravascular and intravenous
administration, respectively, and
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and
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are the administered
extravascular and intravenous doses.
Source:
PAC, 2004, 76, 1033
(Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003))
on page 1041