Lowest concentration or
amount of a substance, found by experiment or observation, which
causes an adverse alteration of
morphology, functional capacity,
growth, development, or life span of a target organism distinguishable
from normal (control) organisms of the same species and
strain under
defined conditions of
exposure.
Source:
PAC, 1993, 65, 2003
(Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993))
on page 2065
PAC, 2001, 73, 993
(Risk assessment for occupational exposure to chemicals. A review of current methodology
(IUPAC Technical Report))
on page 1023
This definition replaces an earlier definition of
.