Lipophilicity represents the affinity of a molecule or a
moiety for a
lipophilic environment. It is commonly measured by its distribution
behaviour in a biphasic system, either liquid-liquid (
e.g.,
partition
coefficient in 1-octanol/water) or solid-liquid (retention on
reversed-phase high-performance liquid
chromatography (
RP-HPLC)
or
thin-layer chromatography (
TLC) system).
Source:
PAC, 1997, 69, 1137
(Glossary of terms used in computational drug design (IUPAC Recommendations 1997))
on page 1145
PAC, 1994, 66, 1077
(Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994))
on page 1123
PAC, 1972, 31, 577
(Manual of Symbols and Terminology for Physicochemical Quantities and Units, Appendix
II: Definitions, Terminology and Symbols in Colloid and Surface Chemistry)
on page 607
Cite as:
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by
A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997).
XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic,
J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
https://doi.org/10.1351/goldbook.
