A measure of the capability of a solute for
hydrophobiclipophilic interaction based on the
partition coefficient
for distribution of the solute between octan-1-ol and water. The most general way
of applying
in
correlation analysis,
QSAR, etc. is as log
, but the behaviour of substituted benzene derivatives may be quantified by a substituent
constant scale,
, which is defined in a way analogous to the Hammett σ scale. There are various scales,
depending on the substrate series used as reference.
Source:
PAC, 1994, 66, 1077
(Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994))
on page 1119
Cite as:
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by
A. D. McNaught and A.Wilkinson. Blackwell Scientific Publications, Oxford (1997).
XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic,
J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
https://doi.org/10.1351/goldbook.
