The graph of the relation between
dose and the proportion of
individuals responding with an all-or-none effect; it is essentially the
graph of the
probability of an occurrence (or the proportion of a
population exhibiting an effect) against
dose. Typical examples of
such all-or-none effects are mortality or the incidence of cancer.
The
dose-effect curve is the graph of the relation between
dose
and the magnitude of the biological change produced measured in
appropriate units. It applies to measurable changes giving a graded
response to increasing doses of a
drug or
xenobiotic. It represents the
effect on an individual animal or person, when biological variation is
taken into account. An example is the increased effect of lead on the
haem synthesis,
e.g., on activity of the enzyme 6-amino laevulinic
acid dehydratase in blood
serum or coproporphyrin levels in urine.
Source:
PAC, 2001, 73, 993
(Risk assessment for occupational exposure to chemicals. A review of current methodology
(IUPAC Technical Report))
on page 1022
Cite as:
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by
A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997).
XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic,
J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
https://doi.org/10.1351/goldbook.
