Comparative Molecular Field Analysis (
CoMFA) is a
3D-QSAR
method that uses statistical correlation techniques for the analysis of
the quantitative relationship between the biological activity of a set of
compounds with a special alignment, and their three-dimensional
electronic and steric properties. Other properties, such as
hydrophobicity and H-bonding, can also be incorporated into the
analysis.
Source:
PAC, 1997, 69, 1137
(Glossary of terms used in computational drug design (IUPAC Recommendations 1997))
on page 1140
Cite as:
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by
A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997).
XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic,
J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.
https://doi.org/10.1351/goldbook.
